Most calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Modify Therapy/Monitor Closely. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Use Caution/Monitor. Applies only to oral form of both agents. There are physiological variation in iron reserves such as the decrease during menstruation period. Administer while the patient is in a reclined or semi-reclined position. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. Use Caution/Monitor. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Manage and view all your plans together even plans in different states. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. Applies only to oral form of both agents. Do not administer Venofer to patients with iron overload. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. This may be helped by giving the medication more slowly or at a lower dose. Many patients with kidney disease cannot get enough iron from food and require injections. Use Caution/Monitor. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Observed Hb = the patients current hemoglobin in g/dl. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. This product may contain inactive ingredients, which can cause allergic reactions or other problems. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. I. Iron Deficiency Calculator For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Copyright 2021 GlobalRPH - Web Development by. Before using, check this product visually for particles or discoloration. Applies only to oral form of both agents. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Calculation of the Total Iron Deficit - Alternative equation Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Administer Venofer early during the dialysis session (generally within the first hour). Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Iron sucrose: 20 mg/mL. Applies only to oral form of both agents. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. Applies only to oral form of both agents. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. A: Generally acceptable. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Pediatric Patients (2 Years of Age and Older). Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Use Caution/Monitor. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Methods. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Avoid or Use Alternate Drug. Venofer must only be administered intravenously either by slow injection or by infusion. Applies only to oral form of both agents. Volume of iron product required = 25 mL. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Deferasirox chelates iron. These can be input in g/dL, g/L or mmol/L. Either decreases levels of the other by inhibition of GI absorption. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. 1. Iron Sucrose - Injection - Alberta 2012;2(4):288-335. Fulminant symptoms include confusion, sensation of passing out, paleness. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. To view formulary information first create a list of plans. IDA diagnosis is based on full blood examination and on the serum ferritin level. Use Caution/Monitor. Applies only to oral form of both agents. Administer Venofer early during the dialysis session (generally within the first hour). Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Venofer Dosing and Administration Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Applies only to oral form of both agents. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. This site contains information for licensed healthcare professionals in the United States. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Please confirm that you would like to log out of Medscape. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. J Lab Clin Med; 111(5):566-70. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. By using this form you agree with the storage and handling of your data by this website. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. . Applies only to oral form of both agents. Applies only to oral form of both agents. DICP. Due Date form Ultrasound Report. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Deferoxamine chelates iron. Applies only to oral form of both agents. Applies only to oral form of both agents. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Separate dosing of tetracyclines from these products. Medicinal forms Separate by 2 hr. Avoid or Use Alternate Drug. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. Minor/Significance Unknown. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Jacobs P, Dommisse J. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Compare formulary status to other drugs in the same class. Venofer / Products / American Regent DailyMed - VENOFER- IRON SUCROSE injection, solution Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Use Caution/Monitor. 1 ,*. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Venofer (iron sucrose) dosing, indications, interactions, adverse Use Caution/Monitor. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Avoid or Use Alternate Drug. Initial infusion rate. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Applies only to oral form of both agents. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Assessing new treatment options. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Iron Sucrose (Ferogen): Indications, Dosage, Administration - Medcrine Dosing Administration & Considerations . famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Avoid or Use Alternate Drug. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Applies only to oral form of both agents. Information last revised December 2022. Use Caution/Monitor. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Applies only to oral form of both agents. Interaction only with oral iron administration. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. This site complies with the HONcode standard for trust- worthy health information: verify here. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Kidney Int. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Applies only to oral form of both agents. Ferrlecit may also be administered undiluted as a slow intravenous injection (at a rate of up to 12.5 mg/min) per dialysis session. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. PDF Protocol for the use of Intravenous Iron Sucrose (Venofer Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Patients measured hemoglobin can be input in g/dL or mmol/L. Applies only to oral form of both agents. 1988 May;111(5):566-70. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion .